test_2x2_rom_cpp — test_2x2

Description : to simulate a 2x2 design and return the p-tost for ratio of means (ROM)

test_2x2_rom(
  n,
  muT,
  muR,
  SigmaW,
  lequi_tol,
  uequi_tol,
  alpha,
  sigmaB,
  dropout,
  Eper,
  Eco,
  typey,
  adseq,
  k,
  arm_seed
)

Arguments

n: integer number of subjects per sequence
muT: vector mean of endpoints on treatment arm
muR: vector mean of endpoints on reference arm
SigmaW: matrix within subject covar-variance matrix across endpoints
lequi_tol: vector lower equivalence tolerance band across endpoints
uequi_tol: vector upper equivalence tolerance band across endpoints
alpha: vector alpha value across endpoints
sigmaB: double between subject variance (assumed same for all endpoints)
dropout: vector of size 2 with dropout proportion per sequence (0,1)
Eper: vector of size 2 with period effect on period (0,1)
Eco: vector of size 2 with carry over effect of arm c(Reference, Treatment).
typey: vector with positions of primary endpoints
adseq: boolean is used a sequential adjustment?
k: integer minimum number of equivalent endpoints
arm_seed: seed for the simulation

mat(vector) with ptost and other simulated statistics such as mean (mu) and standard deviation(std) per sequence (0,1)-endpoint