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The incremental value of cardiovascular risk factors

Tzoulaki.Rd

Tzoulaki et al. (2009) reviewed studies that evaluated various candidate prognostic factors in their ability to improve prediction of coronary heart disease (CHD) or other outcomes beyond what the Framingham risk score (FRS) can achieve.

Usage

data("Tzoulaki")

Format

A data frame containing data from 27 studies on the following 2 variables.

PubmedID

a character vector with the Pubmed ID of the study

N

a numeric vector describing the study size

N.events

a numeric vector describing the observed number of events

FRS.orig.refitted

a boolean vector describing whether the coefficients of the original Framingham Risk Score (FRS) were re-estimated

FRS.modif.refitted

a boolean vector describing whether the coefficients of the modified Framingham Risk Score were re-estimated

predictors

a character vector indicating which new risk factor(s) were included in the modified FRS

outcome

a character vector indicating the primary outcome being predicted

AUC.orig

a numeric vector describing the Area under the ROC curve (AUC) of the original FRS model

AUC.orig.CIl

a numeric vector describing the lower boundary of the 95% confidence interval of the AUC of the original FRS model

AUC.orig.CIu

a numeric vector describing the upper boundary of the 95% confidence interval of the AUC of the original FRS model

AUC.modif

a numeric vector describing the Area under the ROC curve (AUC) of the modified FRS model that includes one or more new risk factors

AUC.modif.CIl

a numeric vector describing the lower boundary of the 95% confidence interval of the AUC of the modified FRS model

AUC.modif.CIu

a numeric vector describing the upper boundary of the 95% confidence interval of the AUC of the modified FRS model

pval.AUCdiff

a numeric vector with the p-value of the difference between AUC.orig and AUC.modif

sign.AUCdiff

a boolean vector indicating whether the difference between AUC.orig and AUC.modif is below 0.05

Source

Tzoulaki I, Liberopoulos G, Ioannidis JPA. Assessment of claims of improved prediction beyond the Framingham risk score. JAMA. 2009 Dec 2;302(21):2345–52.

Examples

data(Tzoulaki)
## maybe str(Tzoulaki) ; plot(Tzoulaki) ...